CURRICULUM VITAE                                      

                                                                                                                                                           

Date Prepared:                 02/01/06                                   

                                                                               

Name:                              Ellen W. Seely

 

Address:                           83 Blake Road, Brookline, MA  02445

 

Office Address:                Endocrinology, Diabetes and Hypertension Division

                                        Brigham and Women’s Hospital

                                        221 Longwood Ave.

                                        Boston, MA 02115

 

Email:                     eseely@partners.org                  

 

Fax:                                  617-732-5764

Phone:                              617-732-5661

 

Place of Birth:                   New York, New York

 

Education:             

 

          1977 B.A.              Brown University, Providence

          1981 M.D.             Columbia University College of Physicians and Surgeons

 

Postdoctoral Training:

 

          Internship and Residencies:

 

          1981-1984             First, Second and Third Year Resident Physician, Brigham and Women's Hospital, Boston MA

          1981-1984             Clinical Fellow in Medicine, Harvard Medical School, Boston MA

 

          Research Fellowships:

 

          1984-1987             Research/Clinical Fellow in Medicine, Brigham and Women’s Hospital, Boston MA

          1984-1987             Research Fellow in Medicine, Harvard Medical School, Boston MA

 

Licensure and Certification:

 

          1984                      Massachusetts License Registration

          1984                      American Board of Internal Medicine

          1987                      American Board of Internal Medicine Endocrinology and Metabolism

1999                     International Society of Bone Densitometry Certification

Academic Appointments:

 

          1987-1991             Instructor in Medicine, Harvard Medical School, Boston MA

          1991- 2001            Assistant Professor in Medicine, Harvard Medical School, Boston MA

          2001-                     Associate Professor in Medicine, Harvard Medical School, Boston MA

         

Hospital Appointments:

 

          1987-1995             Associate Physician, Brigham and Women's Hospital, Boston, MA

          1988- 1995            Associate Physician, Beth Israel Hospital, Boston, MA

          1996-                     Physician, Brigham and Women's Hospital

1997-                     Clinical Associate in Medicine, Mass General Hospital

 

Other Professional Positions and Major Visiting Appointments:

 

          1987-                     Director of Clinical Research, Endocrine-Hypertension Division, Brigham and Women's Hospital, Boston, MA

          1993-1994             Co-Director, Endocrinology and Metabolism Training Program, Brigham and Women's Hospital

          1994-                     Consultant in Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA

          1995- 1997            Director Ambulatory Clinical Center and Endocrine-Hypertension Diabetes Ambulatory Clinic, Brigham and Women's Hospital, Boston, MA

          1995-                     Associate Program Director General Clinical Research Center, Brigham and Women's Hospital, Boston, MA

          1997-                     Director, Inpatient Clinical Research Center, Brigham and Women’s Hospital, Boston MA

          1997-                     BWH Clinical Trials Advisory Board

2000-                     Faculty Mentor, Department of Medicine’s Mentoring Program, BWH

2001-                     Member, Center of Excellence in Women’s Health, Harvard Medical     School

 

Editorial Boards:

 

          1999-2002             Member, Journal Clinical Endocrinology and Metabolism

1999- 2004            Associate Editor, Endocrinology, Harvard Medical School Family Guide Online Edition        

2000-                     Consulting Editor, Harvard Medical School-InteliHealth

2004-                     Member, Endocrine Today

                              Member, Journal Clinical Endocrinology and Metabolism

2005-                     Member, Journal Clinical Endocrinology and Metabolism

Co-editor, Tri-Point Series, Endocrine News

 

 

 

 

 

Awards and Honors:

 

          1977                      Sigma Xi, Brown University

          1977                      Honors thesis in biology, Brown University

          1977                      B.A., Magna Cum Laude, Brown University

          1987                      Marion Young Investigator Award Finalist, Council for High Blood

                                        Pressure Research

          1992-2000             Henry A. and Camillus Christian Fellowship, Harvard Medical School

          1994-1996             Capps Scholar in Diabetes, Harvard Medical School

          1998-1999             Harvard Medical School Scholar in Medicine

          1999                      Hypertension Specialist in Clinical Hypertension, American Society of

                                        Hypertension

          2000                      Smith-Kline Beecham Faculty Award in Diabetes

          2001                      Harvard Medical School, A. Clifford Barger Excellence in Mentoring Award

 

 

Major Committee Assignments:

 

          1983-1994             Medical Internship Selection Committee, Brigham and Women's Hospital

          1993-1994             Department of Medicine Credentials Committee

          2001-                     Harvard Medical School Admissions Committee

2003-                     Research Affairs Committee, Endocrine Society

2004                        Member, Obesity Advisory Board, Endocrine Society

 

Memberships in Professional Societies:

 

          1989-                     Member, Endocrine Society

          1989-                     Member, American Federation for Clinical Research

          1992-                     Member, International Society for the Study of Hypertension in Pregnancy

          1993-                     Member, American Diabetes Association

          1995-                     Fellow, Council for High Blood Pressure Research   

1996-                     Member, American Society of Hypertension

          1999-                     Member, North American Menopause Society

2001-                     Member, North American Society for the Study of Hypertension in Pregnancy

2005-                     Member, Cares (Congenital Adrenal Hyperplasia Research, Education and Support) Foundation Medical Advisory Board 

                              Secretary/Treasurer, Association for Patient Oriented Research

            

 

Major Research Interests:

 

          1.       Pregnancy-induced hypertension and gestational diabetes

 

2.              Effect of female sex hormones on blood pressure regulation

 

 

BIBLIOGRAPHY:

 

          Articles

 

1.      Fischer A, Benis A, Jurado R, Seely EW, Teirstein P, Litwak R.  Analysis of errors in measurement of cardiac output by simultaneous dye and thermal dilution in cardiothoracic surgical patients.  Cardiovasc Res 1978; 12:190-9.

 

2.      Brent GA, LeBoff MS, Seely EW, Conlin PR, Brown EM.  Relationship between the concentration and rate of change of calcium and serum levels of intact parathyroid hormone in normal humans.  J Clin Endocrinol Metab 1988; 67:944-50.

 

3.      Seely EW, Moore TJ, Rogacz S, Gordon M, Gleason RE, Hollenberg NK, Williams GH.  Angiotensin-mediated renin suppression is altered in non-modulating hypertension.  Hypertension 1989; 13:31-7.

 

4.      Seely EW, LeBoff MS, Chen C, Posillico JT, Brown EM, Hollenberg NK, Williams GH.  The calcium-channel blocker diltiazem lowers parathyroid hormone (PTH) levels in vivo and in vitro.  J Clin Endocrinol Metab 1989; 68:1007-12.

 

5.      Seely EW, Moore TJ, LeBoff MS, Brown EM.  A single dose of lithium carbonate acutely elevates intact parathyroid hormone levels in humans.  Acta Endocrinol, (Copenh) 1989; 121:174-6.

 

6.      Seely EW, Conlin PR, Brent GA, Dluhy RG.  Adrenocorticotropin stimulation of aldosterone:  prolonged continuous versus pulsatile infusion.  J Clin Endocrinol Metab 1989; 69:1028-32.

 

7.      Mandel SJ, Larsen PR, Seely EW, Brent GA.  Increased need for thyroxine during pregnancy in women with primary hypothyroidism.  N Engl J Med 1990; 323:91-96.

 

8.      Seely EW, Williams GH, Graves SW.  Markers of sodium homeostasis in pregnancy-induced hypertension.  J Clin Endocrinol Metab 1992; 74:150-6.

 

9.      Jacobus CH, Holick MF, Shao Q, Chen TC, Holm IA, Kolodny JM, Fuleihan GEH, Seely EW.  Hypervitaminosis D associated with drinking milk.  N Engl J Med 1992; 326:1174-7.

 

10.  Seely EW, Wood RJ, Brown EM, Graves SW.  Lower serum ionized calcium and abnormal calciotropic hormone levels in preeclampsia.  J Clin Endocrinol Metab 1992; 74:1436-40.

 

11.  Grant FD, Mandel SJ, Brown EM, Williams GH, Seely EW.  Interrelationships between the renin-angiotensin-aldosterone and calcium homeostatic systems.  J Clin Endocrinol Metab 1992; 75:988-992.

 

12.  Graves SW, Moore TJ, Seely EW.  Increased platelet angiotensin II number in women with pregnancy-induced hypertension.  Hypertension 1992; 20:627-632.

 

13.  Donovan DS, Solomon CG, Seely EW, Williams GH, Simonson DC.  Effect of sodium intake on insulin sensitivity.  Am J Physiol 264 (Endocrinol Metab 27) 1993; E730-E734.

 

14.  Klein T, Martens H, Dijk D-J, Kronauer RE, Seely EW, Czeisler CA.  Circadian sleep regulation in the absence of light perception:  Chronic non-24-hour circadian rhythm sleep disorder in a blind man with a regular 24-hour sleep-wake schedule.  Sleep 1993; 16:333-43.

 

15.  Seely EW, Canessa ML, Graves SW.  Impact of diabetes on sodium-lithium-countertransport in pregnancy-induced hypertension.  Am J Hypertens 1993; 6:422-426.

 

16.  Ridker PM, Gaboury CL, Conlin PR, Seely EW, Williams GH, Vaughan DE.  Stimulation of plasminogen activator inhibitor in vivo by infusion of angiotensin II.  Evidence of a potential interaction between the renin-angiotensin system and fibrinolytic function.  Circulation 1993; 87(6):1969-73.

 

17.  Graves SW, Wood RJ, Brown EM, Seely EW.  Calcium and calciotropic hormones in transient hypertension of pregnancy versus preeclampsia.  Hypertens in Pregnancy 1994; 13:87-95.

 

18.  Emanuel RL, Robinson BG, Seely EW, Graves SW, Kohane I, Saltzman D, Barbieri R, Majzoub JA.  Corticotropin releasing hormone levels in human plasma and amniotic fluid during gestation.  Clin Endocrinol 1994; 40:257-262.

 

19.  Gandhi RT, Tollin SR, Seely EW.  Diagnosis of candida thyroiditis by fine needle aspiration. J Infection 1994; 28:77-81.

 

20.  Graves SW, Wood RJ, Brown EM, Seely EW.  Calcium and calciotropic hormones in transient hypertension of pregnancy versus preeclampsia.  Hypertens in Pregnancy 1994; 13:87-95.

 

21.  Tollin SR, Seely EW.  Postpartum hypopituitarism in a patient with sickle cell trait: Case report and literature review.  Am J Med Sci 1994; 308:35-37.

 

22.  Szal SE, Repke JT, Seely EW, Graves SW, Parker CA, Morgan KG. [Ca2+]i signaling in pregnant human myometrium. Am J Physiol 267 (Endocrinol Metab 30) 1994; E77-E87.

 

23.  Solomon CG, Graves SW, Greene MF, Seely EW.  Glucose intolerance as a predictor of hypertension in pregnancy. Hypertens 1994;23:717-721.

 

24.  Gaboury CL, Simonson DL, Seely EW, Hollenberg NK, WIlliams GH. Relation of pressor responsiveness to angiotensin II and insulin resistance in hypertension. J Clin Invest 1994; 94:2295-2300.

 

25.  Graves SW, Lincoln K, Cook SL, Seely EW.  Digitalis-like factor and digoxin-like immunoreactive factor in diabetic women with preeclampsia, transient hypertension of pregnancy, and normotensive pregnancy.  Am J Hypertens 1995; 8:5-11.

 

26.  Solomon CG, Thiet MP, Moore F, Seely EW.  Primary hyperaldosteronism in pregnancy. A case report.  J Reprod Med 1996; 41:255-258.

 

27.  Seely EW, Brown EM, DeMaggio DM, Weldon DK, Graves SW.  A prospective study of calciotropic hormones in pregnancy and the postpartum state: Reciprocal changes in serum intact parathyroid hormone and 1,25-dihydroxyvitamin D. Am J Ob Gyn 1997; 176:214-17.

 

28.  Fisher ND, Ferri C, Bellini C, Santucci A, Gleason R, Williams GH, Hollenberg NK, Seely EW.  Age, gender and nonmodulation:  A sexual dimorphism in essential hypertension.  Hypertension 1997; 29:980-985.

 

29.  Maxwell CV, Tao Q-F, Seely EW, Repke JT, Graves SW.  Regulation of the sodium pump in pregnancy-related tissues in preeclampsia.  Am J Ob Gyn 1998; 179:28-34.

 

30.  Conlin PR, Seely EW, Hollenberg NK, Williams GH.  Dissociation of vascular and adrenal responsiveness to angiotensin II following calcium channel blockade. Endo Res 1998; 24:127-139.

 

31.  Gerhard M, Walsh BW, Tawakol A, Hadley EA, Creager SJ, Seely EW, Ganz P, Creager MA.  Estradiol therapy combined with progesterone and endothelium-dependent vasodilation in postmenopausal women.  Circulation 1998;98:1158-1163.

 

32.  Solomon CG, Carroll JC, Okamura K, Graves SW, Seely EW.  Higher cholesterol and insulin levels in pregnancy are associated with increased risk for pregnancy- induced hypertension. Am J Hypertens 1999; 12:276-282.

 

33.  Mahmoudi, N, Graves SW, Solomon CG, Repke JT, Seely EW. Eclampsia: A 13-year experience at a United States tertiary care hospital. J Wom Health 1999; 8:495-500.

 

34.  Seely EW, Walsh BW, Gerhard MD, Williams GH. Estradiol with or without progesterone and 24 hour ambulatory blood pressure in postmenopausal women. Hypertension 1999;33:1190-1194.

 

35.  Ochoa-Maya MR, Frates MC, Lee-Parritz, Seely EW.  Resolution of fetal goiter after discontinuation of propylthiouracil in a pregnant woman with Graves’ hyperthyroidism.  Thyroid 1999;11: 1111-1114.

 

36.  Wyckoff JA, Seely EW, Hurwitz S, Anderson BF, Lifton RP, Dluhy RG. Glucocorticoid-remediable aldosteronism and pregnancy. Hypertension 2000;35:668-672.

 

37.  Solomon CG, Connelly MT, Collins K, Okamura K, Seely EW.  Provider characteristics: Impact on bone density utilization at a health maintenance organization. Menopause 2000; 7:391-394.

 

38.  Marqusee E, Braverman LE, Lawrence JE, Carroll JS, Seely EW.  The effect of droloxifene and estrogen on thyroid function in postmenopausal women.  J Clin Endocrinol Metab 2000; 85:4407-4410.

 

39.  Raji A, Williams GH, Xavier J, Hopkins PN, Hunt SC, Hollenberg NK, Seely EW.  Insulin resistance is affected by sodium intake in non-modulating subset of essential hypertension. J Hypertens 2001; 19-99-105.

 

40.  Carrol JS, Seely EW, Qing-Fang T, Graves SW.  Digitalis-like factor response to hyperinsulinemia accompanying euglycemic hyperinsulinemic clamp or oral glucose tolerance test.  Life Science 2001; 69(7):829-837.

 

41.  Maxwell C, Lieberman E, Norton M, Seely EW, Lee-Parritz A.  Relationship of twin    zygosity and preeclampsia.  Am J Obstet Gynecol 2001; 185(4):819-21.

 

42.  Herrington DM, Brosnihan KB, Pusser BE, Seely EW, Ridker PM, Rifai N, MacLean DB. Differential effects of E and droloxifene on C-reactive protein and other markers of inflammation in healthy postmenopausal women.  J Clinical Endocrinol Metab 2001; 86:  4216-4222.

 

43.  Bradbury RA. Cropley J. Kifor O. Lovicu FJ. de Iongh RU. Kable E. Brown EM. Seely EW. Peat BB. Conigrave AD. Localization of the extracellular Ca (2+)-sensing   receptor in the human placenta. Placenta 2002; 23(2-3):192-200.

 

44.  Seely EW, Carrol JA, Goodfriend TL, Tao Q-F, Graves SW.  Digitalis-like factor response to hyperinsulinemia in human pregnancy, a model of insulin resistance.  J Hum Hypertens 2002; 16(12): 851-6.

 

45.  Raji A, Seely EW, Bekins SA, Williams GA, Simonson DC.  Rosiglitazone improves insulin sensitivity and lowers blood pressure in hypertensive patients.  Diabetes Care 2003; 26(1):172-178.

 

46.  Seely EW, Brosnihan KB, Jeunemaitre X, Okamura K, Williams, MD GH, Hollenberg NK, Herrington DM. Effects of conjugated estrogen and droloxifene on the renin-angiotensin system, blood pressure and renal blood flow in postmenopausal women.Clinical Endocrinology, 2004; 60:315-321.

 

47.  Wolf M, Hubel CA, Lam C, Sampson M, Ecker JL, Ness RB, Rajakumar A, Daftary A, Shakir AS, Seely EW, Roberts JM, Sukhatme VP, Karumanchi SA, Thadhani R. Preeclampsia and future cardiovascular disease: Potential role of altered angiogenesis and insulin resistance. J Clin Endocrinol Metab. 2004; 89:6239-6243.

 

48.  Turchin A, Wiebe DA, Seely EW, Graham T, Longo W, Soiffer R. Severe        

                 hypercholesterolemia mediated by lipoprotein X in patients with hypo chronic

 graft-versus-host disease of the liver. Bone Marrow Transplantation. 2005; 35:85-89.

 

49.  Bentley-Lewis R, Graves SW, Seely EW. The renin-aldosterone response to     stimulation and suppression during normal pregnancy. Hypertension in Pregnancy. 2005; 24:1-16.

 

50.  Wyatt JW, Frias JL, Hoyme HE, Jovanovic L, Kaaja R, Brown F, Garg S, Lee- Parritz A, Seely EW, Kerr L, Mattoo V, Tan M, and the IONS study group. Congenital anomaly rate in offspring of mothers with diabetes treated with insulin lispro during pregnancy.  Diabetes Medicine 2005; 22:803-7.

 

51.  Heitritter S, Solomon CG, Mitchell G, Skali NO, Seely EW.  Subclinical 

  inflammation and vascular dysfunction in women with prior gestational diabetes.

   J Clin Endocrinol Metab 2005; 90:3983-88.

 

 

              

      Reviews, Chapters and Editorials

 

1.      Seely EW, Williams GH.  The cardiovascular system and endocrine disease.  In:Becker KL, ed. Principles and Practice of Endocrinology and Metabolism,  Philadelphia:  J.B. Lippincott Co. 1990:1496-1503.

 

2.      Seely EW, Williams GH.  The endocrine heart.  In:  Becker KL, ed.  Principles and Practice of Endocrinology and Metabolism, Philadelphia:  J.B. Lippincott Co. 1990:1347-1351.

 

3.      Seely EW, Moore TM.  Adrenal gland physiology and function.  In:  May HL, ed.  Emergency Medicine, Boston:  Little, Brown and Co. 1992:1247-1252.

 

4.      Moore TM, Seely EW.  Adrenal insufficiency.  In:  May HL, ed.  Emergency Medicine, Boston:  Little, Brown and Co. 1992:1253-1259.

 

5.      Graves SW, Seely EW, Williams GH.  Genes, phenotypes and hypertensive pregnancies.  Nat Genet 1993; 4:7-8.

 

6.      Seely EW, Graves SW.  Calcium homeostasis in normotensive and hypertensive pregnancy.  Comprehensive Therapy 1993; 19:124-128.

 

7.      Seely EW, Graves SW.  Hormonal control of volume in the nonpregnant and pregnant state.  Staff and Resident Physician 1994; 40: 23-24.

 

8.      Seely EW, Moore TM.  The renin-angiotensin-aldosterone system and vasopressin.  In:  Tulchinsky D and Little B, eds.  Maternal-Fetal Endocrinology, 2nd edition, W.B. Saunders, 1994.

 

9.      Jaffe LS and Seely EW.  Diabetes.  In: Eisenstat S and Carlson K, ed.  The Primary Care of Women, Mosby-Yearbook, Inc., 1995.

 

10.  Jaffe LS, Seely EW.  Hypertension in women: extent and limit of our knowledge.  Curr Probl Obstet Gynecol Fertil 1995; XVII: 1-36.

 

11.  Solomon CG, Seely EW. Thyroid disease and pregnancy. In: Carr PL and Freund KM, ed.  The Medical Care of Women, W.B. Saunders, 1995

 

12.  Jaffe LS, Seely EW.  The heterogeneity of the blood pressure response to hormonal contraceptives.  Current Opinion in Endocrinology and Diabetes 1995; 2:257-265.

 

13.  Seely EW, Williams GH.  The cardiovascular system and endocrine disease.  In:  Becker KL, ed.  Principles and Practice of Endocrinology and Metabolism, 2nd edition, Philadelphia:  J.B. Lippincott Co. 1990:1496-1503.

 

14.  Seely EW, Graves SW, Repke JT.  Hypertension during pregnancy. In: Smith TW (ed.) Cardiovascular Therapeutics.  W.B. Saunders, 1996.

 

15.  Graves SW, Jaffe LS, Seely EW.  The role of anterior pituitary hormone measurements in the evaluation of pituitary hypofunction. Staff and Resident Physician 1997; 43:23-33.

 

16.  Williams GH, Lilly L, Seely EW.  The heart in endocrine and nutritional disorders.  In: Braunwald, EB (ed).  Heart Disease.  WB Saunders 1997.

 

17.  Seely EW, Lindheimer MD.  Pathophysiology of preeclampsia.  In: Izzo JL, Black HR (eds) Hypertension Primer, 2nd Edition.  American Heart Association 1999. Dallas, TX.

 

18.  Seely EW.  Hypertension in pregnancy: A potential window into long-term cardiovascular health in women. J Clin Endocrinol Metab 1999; 84:1858-1861.

 

19.  Seely EW, Williams GH. The cardiovascular system and endocrine disease.  In:  Becker KL, ed.  Principles and Practice of Endocrinology and Metabolism, 3rd edition, Philadelphia:  J.B. Lippincott Co. 2001.

 

20.  Seely EW, Williams GH.  The heart in endocrine and nutritional disorders.  In: Braunwald (ed.). Heart Disease, 6th edition.  WB Saunders 2001.

 

21.  Solomon CG, Seely EW.  Hypertension in pregnancy:  A manifestation of the insulin resistance syndrome?  Hypertension 2001; 37:232-239.

 

22.  Seely EW, Solomon CG.  Treatment of hypertension in pregnancy.  www.Harrisononline.com.2001

 

23.  Jaffe LS and Seely EW. Diabetes.  In: Eisenstat S and Carlson K, ed.  The Primary Care of Women, Mosby-Yearbook, 2nd Edition. Inc. 2002.

 

24.  Seely EW, Solomon CG.  Insulin resistance and its potential role in pregnancy- induced hypertension. 2003; J Clin Endocrinol Metab 88:2393-2398.

 

25.  Solomon CG, Seely EW. Polycystic ovarian syndrome.  In: Izzo JL, Black HR (eds) Hypertension Primer, 3rd Edition.  American Heart Association 2003.  Dallas, TX

 

26.  Seely EW, Lindheimer MD.  Pathophysiology of preeclampsia.  In: Izzo JL, Black HR (eds) Hypertension Primer, 3rd Edition.  American Heart Association 2003. Dallas, TX.

 

27.  Solomon CG, Seely EW. Preeclampsia-Searching for a cause. New England Journal Medicine 2004; 350: 641-2.

 

28.  Solomon CG, Seely EW. Lower incidence of diabetes seen among hormone therapy users in The Women’s Health Initiative Comment. North America Menopause Society 2004 www.menopause.org/news.html

 

29.  Ecker JL, Seely EW. Medical complications in pregnancy. Women’s Health. ACP Medicine Online. Dale DC, Federman DD, Eds. WebMD Inc., New York, 2005. kttp://acpmedicine.com. December, 2005.

 

30.  Solomon CG, Seely EW.   Hypertension in Pregnancy.  Endocrinology and Metabolism Clinics of North America.  2006;  35: 151-171.

 

31.  Seely EW. Does treatment of gestational diabetes affect pregnancy outcome? Nature Clin Pract Endocrinol Metab 2006;2:72-73.