DESCRIPTION: State the application’s broad, long-term objectives and specific aims, making reference to the health relatedness of the project. Describe concisely the research design and methods for achieving these goals. Avoid summaries of past accompl

BIOGRAPHICAL SKETCH

Provide the following information for the key personnel in the order listed on Form Page 2.

Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME

Emil J Freireich, M.D..

POSITION TITLE

Professor of Medicine

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATION

DEGREE

(if applicable)

YEAR(s)

FIELD OF STUDY

U of Illinois College of Medicine

D.Sc.(Hon)

1947

1949

Medicine

A. Positions and Honors.

Positions and Employment

1949-1950 Internship, Cook County Hospital, Chicago, Illinois

1950-1953 Residency in Internal Medicine, Presbyterian Hospital, Chicago, Illinois

1953-1955 Research Associate in Hematology, Massachusetts Memorial Hospital, Boston, Massachusetts

1955-1965 Senior Investigator and Head, Leukemia Service, National Cancer Institute, Bethesda, Maryland

1965-Present Professor of Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, Texas

1965-1983 Deputy Head and Head, Department of Developmental Therapeutics

1981-Present Ruth Harriet Ainsworth Professor of Medicine

1985-Present Director, Adult Leukemia Research Program

2000-Present Director, Special Medical Education Programs

Honors

1972 Albert Lasker Medical Research Award

1976 Seventh Annual David A. Karnofsky Award and Lecture, American Society of Clinical Oncology

1979 Robert Roesler de Villiers Award of the Leukemia Society of America, Inc.

1983 Charles F. Kettering Prize of the General Motors Cancer Research Foundation

1990 Distinguished Alumni Award, National Institutes of Health, Initial Awardee

1991 First Allen Latham, Jr. Award for Scientific Contribution to the Development of Apheresis of the European Society of Haemapheresis, Wurzburg, Germany

1994 C. Edwin Cohn-C de Laval Award, World Apheresis Association

1996 Medical Oncology Fellows Outstanding Teacher Award, M. D. Anderson Cancer Center, Houston, TX

1997 Festschrift Symposium in Honor of 70^th Birthday (Clin Cancer Res 3(12):2550-2734, 1997)

2000 Alumni Achievement Award, University of Illinois Chicago

2000 Faculty Achievement Award for Education, M. D. Anderson Cancer Center, Houston, TX

2000 Charles A. LeMaistre, M.D. Outstanding Achievement Award in Cancer, M. D. Anderson

Cancer Center, Houston, TX

2000 The President’s Award, M. D. Anderson Cancer Center, Houston, TX

2001 Cino del Duca Award (11^th International Congress on Anti-Cancer Treatment), Paris, France

2002 Pollin Prize in Pediatric Research, New York City, NY

B. Selected peer-reviewed publications (Selected from over 675 peer-reviewed publications)

1. Freireich, E.J, Stass, S.A. (eds.): Molecular Basis of Oncology. Blackwell Scientific, Cambridge, MA, pp. 1-426, 1995.

2. Dignani, M.C., Anaissie, E.J., Hester, J.P., O’Brien, S., Vartivarian, S.E., Rex, J.H., Kantarjian, H., Jendiroba, D.B., Lichtiger, B., Andersson, B.J., Freireich, E.J: Treatment of neutropenia-related fungal infections with granulocyte colony-stimulating factor-elicited white blood cell transfusions: A pilot study. Leukemia 11:1621-1630, 1997.

3. Freireich, E.J and Keating, M.J.: Conclusions regarding leukemia long-term survival. Cancer 80(Suppl.S):2215-2217, 1997.

4. Freireich, E.J: The future of clinical cancer research in the next millennium. Clinical Cancer Research 3:2563-2570, 1997.

5. Freireich, E.J: Regulatory issues. IN: Cancer: Principles and Practice of Oncology, 5^th edition (V.T. DeVita, Jr. S. Hellman, S.A. Roenberg, eds.). Lippincott-Raven, Philadelphia, PA pp. 2966-2972, 1997.

6. Jendiroba, D.B., Lichtiger, B., Anaissie, E., Reddy, V., O’Brien, S., Kantarjian, H., Freireich, E.J: Evaluation and comparison of three mobilization methods for the collection of granulocytes. Transfusion 38:722-728, 1998.

7. Freireich, E.J and Albitar, M.: The role of molecular genetics in leukemia diagnosis and therapy. IN: Progress in Anti-Cancer Chemotherapy (G.N. Hortobagyi and D. Khayat, eds.), Blackwell Science, Inc., Malden, Massachusetts, pp.3-12, 1999.

8. Jendiroba, D. B., Lichtiger, B., Freireich, E. J: The use of hematopoietic growth factors for recruitment of leukocytes for transfusion. In: Clinical Applications of Cytokines and Growth Factors (J. R. Wingard and G. D. Demetri, eds.), Kluwer Academic Publishers, Norwell, Massachusetts, pp. 178-185, 1999.

9. Estey, E. H., Thall, P. F., Pierce, S., Cortes, J., Beran, M., Kantarjian, H., Keating, M. J., Andreeff, M., Freireich E.: Randomized phase II study of fludarabine plus cytosine arabinoside plus idarubicin +/- all-trans retinoic acid +/- granulocyte colony-stimulating factor in poor prognosis newly diagnosed acute myeloid leukemia and myelodysplastic syndrome. Blood 93:2478-2484, 1999.

10. Kantarjian, H., O’Brien, S., Smith, T., Cortes, J., Giles, F., Beran, M., Pierce S., Huh, Y., Andreeff, M., Koller, C., Ha, C.S., Keating, M., Murphy, S., Freireich, E.J. Results of treatment with Hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia. Journal of Clinical Oncology 18(3): 547-561, 2000.

11. Faber, J., Kantarjian, H., Roberts, W.M., Keating, M., Freireich, E., Albitar, M. Terminal deoxynucleotidyl transferase-negative acute lymphoblastic leukemia. Archives of Pathology & Laboratory Medicine 124(1): 92-97, 2000.

12. Keating, M.J., Smith, T.L, Lerner, S., O’Brien, S., Robertson, L.E., Kantarjian, H., Freireich, E.J. Prediction of prognosis following fludarabine used as secondary therapy for chronic lymphocytic leukemia. Leukemia & Lymphoma 37(1-2): 71-85, 2000.

13. Chung,C.Y., Kantarjian, H., Haidar, M., Starostik, P., Manshouri, T., Gidel, C., Freireich, E., Keating, M., Albitar, M. Deletions in the 13q14 locus in adult lymphoblastic leukemia. Cancer 88(6): 1359-1364, 2000.

14. Jendiroba, D.B., Freireich, E. Granulocyte transfusions: from neutrophil replacement to immune reconstitution. Blood Reviews 14: 219-227, 2000.

15. Freireich, E. Historical review: Supportive care for patients with blood disorders. British Journal of Haematology 111: 68-77, 2000.

16. Albitar, M., Freireich, E.J: Molecular defects in chronic myeloproliferative disorders. Molecular Medicine 6(7):555-567, 2000.

17. Hester, J., Kellogg, R.M., Mulzet, A.P., Kruger, V.R., McCredie, K.B., Freireich, E. Principles of blood

separation and component extraction in a disposable continuous-flow single-stage channel. (1979)

Historical Article. Therapeutic Apheresis 4(2):98-107, 2000.

18. Keyhani, A., Huh, Y.O., Jendiroba, D., Pagliaro, L., Cortez, J., Pierce, S., Pearlman, M., Estey, E., Kantarjian, H., Freireich, E.J: Increased CD38 expression is associated with favorable prognosis in adult acute leukemia. Leukemia Research 24:153-159, 2000.

19. Albitar, M., Freireich, E.J: Molecular defects in chronic myeloproliferative disorders. Molecular Medicine 6(7):555-567, 2000.

20. Freireich, E.J: Leukemia: Setting the "Stage" for Effective Treatments. OncoLog 46 (1):8, 2001.

21. Ferrajoli, A., Manshouri, T., Estrov, Z., Keating, M.J., O'Brien, S., Lerner, S., Beran, M., Kantarjian, H.M., Freireich, E.J and Albitar, M. High Levels of Vascular Endothelial Growth Factor Receptor-2 Correlate with Shortened Survival in Chronic Lymphocytic Leukemia. Clinical Cancer Research 7: 795-799, 2001.

22. Freireich, E.J: Can we conquer cancer in the twenty-first century? Cancer Chemother. Pharmacol. 48

(Suppl 1):S4-S10, 2001.

23. Giles, F.J., Shen, Y., Kantarjian, H.M., Korbling, M.J., O'Brien, S., Anderlini, P., Donato, M., Pierce, S., Keating, M.J., Freireich, E.J., Estey, E.: Leukapheresis reduces early mortality in patients with acute myeloid leukemia with high white cell counts but does not improve long term survival. Leukemia and Lymphoma 42(1-2):67-73, 2001.

24. Silver, S., Freireich, E.J: Emil J Freireich: a pioneer of modern oncology. The Lancet Oncology (2):514-519, 2001.

25. Keyhani, A., Jendiroba, D.B., Freireich, E.J: Angiogenesis and leukemia. Leukemia Research 25:639-645, 2001.

26. Jendiroba, D.B., Klostergaard, J., Keyhani, A., Pagliaro, L., Freireich, E.J: Effective cytotoxicity against human leukemias and chemotherapy-resistant leukemia cell lines by N-N-dimethylsphingosine. Leukemia Research 26(3):301-310, 2002.

27. Pearlman, M., Jendiroba, D., Pagliaro, L., Keyhani, A., Liu, B., Freireich, E.J: Dexrazoxane in combination with anthracyclines lead to a synergistic cytotoxic response in acute myelogenous leukemia cell lines. Leukemia Research 27(7):617-626, 2003.

28. Kantarjian, H., O’Brien, S., Cortes, J., Giles, F., Thomas, D., Kornblau, S., Shan, J., Rios, M., Keating, M., Freireich, E.: Sudden onset of blastic phase of chronic myelogenous leukemia: patterns and implications. Cancer 98(1):81-85, 2003.

29. Kantarjian, H., Gandhi, V., Cortes, J., Verstovsek, S., Du, M., Garcia-Manero, G., Giles, F., Faderl, S., O’Brien, S., Jeha, S., Davis, J., Shaked, Z., Craig, A., Keating, M., Plunkett, W., Freireich, E.J: Phase 2 clinical and pharmacologic study of clofarabine in patients with refractory or relapsed acute leukemia. Blood 102(7):2379-2386, 2003.

30. Duzkale, H., Pagliaro, L.C., Rosenblum, M.G., Varan, A., Liu, B., Reuben, J., Wierda, W.G., Korbling, M., McMannis, J.D., Glassman, A.B., Scheinberg, D.A., Freireich, E.J Bone marrow purging studies in acute myelogenous leukemia using the recombinant anti-CD33 immunotoxin HuM195/rGel. Biology of Blood & Marrow Transplantation 9(6):364-372, 2003.

31. Safdar, A., Hanna, H.A., Boktour, M., Kontoyiannis, D.P., Hachem, R., Lichtiger, B., Freireich, E.J, Raad, I. I. Impact of high-dose granulocyte transfusions in patients with cancer with candidemia. Cancer 101(12)2859-2865, 2004.

32. Freireich, E.J, Trent, J., Kurzrock, R. New graduate training program for patient-oriented scientists. Letter to the Editor, APOR Newsletter, page 2, December 2004.

33. Freireich, E.J, Kurzrock, R., Estrov, Z. Metastasis—an alternative hypothesis. Cancer 103(8), 2005.