BIOGRAPHICAL SKETCH Provide the following information for the key personnel in the order listed for Form Page 2. Follow this format for each person. DO NOT EXCEED FOUR PAGES.
NAME Marie C. Gelato	POSITION TITLE Professor
EDUCATION/TRAINING  (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION	DEGREE (if applicable)	YEAR(s)	FIELD OF STUDY
Hunter College, New York, NY	BA	1969	Biology
Michigan State Univ, E. Lansing, MI	MS	1972	Physiology
Michigan State Univ, E. Lansing, MI	PhD	1975	Physiology
Michigan State Univ., E. Lansing, MI	MD	1979	Medicine

NOTE: The Biographical Sketch may not exceed four pages. Items A and B, together, may not exceed two of the four-page limit.

 

A.      Positions and Honors. List in chronological order previous positions, concluding with your present position. List any honors. Include present membership on any Federal Government public advisory committee.

 

Positions and Employment

1975-76           Postdoctoral Fellow/Max Planck Institute, Goeftingen, West Germany

1985-87           Senior Staff Fellow/Metabolism Branch/NCI/Bethesda, MD

1987-1997       Director, Clinical Research Center, Univ Hosp Med Center, Stony Brook, NY

1987-1996       Associate Professor/Division of Endocrinology, Stony Brook, Stony Brook, NY

1996-present   Professor/Div of Endocrinology/SUNY at Stony Brook, Stony Brook, NY

1998-present   Program Director, General Clinical Research Center, Univ Hosp Med Center, Stony  Brook, NY

1998-2002       NIH AIDS Study Section Member AARR-6

2000-2003       FDA Advisory Panel for Endocrine and Metabolic Drugs

2001                NIAAA Special Emphasis Panel for RFA AA 01-004-HIV

2002                NIDDK Special Emphasis Panel RFA for Treatment of Lypodystrophy in HIV

2002                NIH Pepper Center Grant Reviews

2002                NIA Ad hoc Review Committee for Contract to establish Intramural Clinical Research Center

2003                NIAID Ad hoc Review Committee for Multicenter AIDS Cohort Study

2004                Editorial Board for JAIDS

2004                NIH/NIDDK review DERC applications

2004                Review Fogarty Fellowships for NIH

2005                NIH/ZRG1 AARR, Chair, Special Emphasis Panel review, ACE member conflict applications

 

Honors

1976-77           Women in Medicine Scholarship: Michigan State University, E. Lansing, MI

1995                Excellence in Teaching Award: SUNY at Stony Brook, Stony Brook, NY

2002                Chancellor’s Award for Excellence in Research, SUNY at Stony Brook, Stony Brook, NY

2001, 2002, 2005 One of the best Doctors in the Tristate Area New York Magazine

 

B.      Selected peer-reviewed publications (in chronological order). Do not include publications submitted or in preparation.

      1.            Gelato MC. Berelowitz M. Insulin-like growth factor-I and insulin-like growth factor binding proteins in the Zucker fattyrat: a case for differential tissue regulation. Advances in Experimental Medicine & Biology. 343:387-96, 1993

      2.            Fan J. Molina PE. Gelato MC. Lang CH. Differential tissue regulation of insulin-like growth factor-I content and binding proteins after endotoxin. Endocrinology. 134(4):1685-92, 1994

      3.            Tsukahara H. Gordienko DV. Tonshoff B. Gelato MC. Goligorsky MS. Direct demonstration of insulin-like growth factor-I-induced nitric oxide production by endothelial cells. Kidney International. 45(2):598-604, 1994

      4.            Frost RA. Bereket A. Wilson TA. Wojnar MM. Lang CH. Gelato MC. Phosphorylation of insulin-like growth factor binding protein-1 in patients with insulin-dependent diabetes mellitus and severe trauma. Journal of Clinical Endocrinology & Metabolism. 78(6):1533-5, 1994

      5.            Bereket A. Lang CH. Blethen SL. Gelato MC. Fan J. Frost RA. Wilson TA. Effect of insulin on the insulin-like growth factor system in children with new-onset insulin-dependent diabetes mellitus. Journal of Clinical Endocrinology & Metabolism. 80(4):1312-7, 1995

      6.            Fan J. Char D. Bagby GJ. Gelato MC. Lang CH. Regulation of insulin-like growth factor-I (IGF-I) and IGF-           binding proteins by tumor necrosis factor. American Journal of Physiology. 269(5 Pt 2):R1204-12, 1995

      7.            Carlson HE. Graber ML. Gelato MC. Hershman JM. Endocrine effects of erythropoietin. International Journal of Artificial Organs. 18(6):309-14, 1995

      8.            Samstein B. Hoimes ML. Fan J. Frost RA. Gelato MC. Lang CH. IL-6 stimulation of insulin-like growth factor binding protein (IGFBP)-1 production. BBRC  228(2):611-5, 1996

      9.            Lang CH. Fan J. Frost RA. Gelato MC. Sakurai Y. Herndon DN. Wolfe RR. Regulation of the insulin-like growth factor system by insulin in burn patients. Journal of Clinical Endocrinology & Metabolism. 81(7):2474-80, 1996

  10.            Gelato MC. Aging and immune function: a possible role for growth hormone.  Hormone Research. 45(1-2):46-9, 1996

  11.            Frost RA. Fuhrer J. Steigbigel R. Mariuz P. Lang CH. Gelato MC. Wasting in the acquired immune deficiency syndrome is associated with multiple defects in the serum insulin-like growth factor system. Clinical Endocrinology. 44(5):501-14, 1996

  12.            Frost RA. Nachman SA. Lang CH. Gelato MC. Proteolysis of insulin-like growth factor-binding protein-3 in human immunodeficiency virus-positive children who fail to thrive. Journal of Clinical Endocrinology & Metabolism.81(8):2957-62,1996

  13.            Bereket A. Wilson TA. Blethen SL. Fan J. Frost RA. Gelato MC. Lang CH. Effect of short-term fasting on free/dissociable insulin-like growth factor I concentrations in normal human serum. Journal of Clinical Endocrinology & Metabolism. 81(12):4379-84, 1996 .

  14.            Lang CH. Pollard V. Fan J. Traber LD. Traber DL. Frost RA. Gelato MC. Prough DS. Acute alterations in growth hormone-insulin-like growth factor axis in humans injected with endotoxin. American Journal of Physiology. 273(1 Pt 2):R371-8, 1997

  15.            Frost RA. Lang CH. Gelato MC. Transient exposure of human myoblasts to tumor necrosis factor-alpha inhibits serum and insulin-like growth factor-I stimulated protein synthesis. Endocrinology. 138(10):4153-9, 1997

  16.            Gelato MC. Frost RA. IGFBP-3. Functional and structural implications in aging and wasting syndromes. [Review] [35 refs] Endocrine. 7(1):81-5, 1997

  17.            McNurlan MA. Garlick PJ. Steigbigel RT. DeCristofaro KA. Frost RA. Lang CH. Johnson RW. Santasier AM. Cabahug CJ. Fuhrer J. Gelato MC. Responsiveness of muscle protein synthesis to growth hormone administration in HIV-infected individuals declines with severity of disease. Journal of Clinical Investigation. 100(8):2125-32, 1997

  18.            Garlick PJ. McNurlan MA. Bark T. Lang CH. Gelato MC. Hormonal regulation of protein metabolism in relation to nutrition and disease. Nutrition. 128(2 Suppl):356S-359S, 1998

  19.            McNurlan MA. Garlick PJ. Frost RA. Decristofaro KA. Lang CH. Steigbigel RT. Fuhrer J. Gelato M. Albumin synthesis and bone collagen formation in human immunodeficiency virus-positive subjects: differential effects of growth hormone administration. Journal of Clinical Endocrinology & Metabolism. 83(9):3050-5, 1998

  20.             Mynarcik DC. Frost RA. Lang CH. DeCristofaro K. McNurlan MA. Garlick PJ. Steigbigel RT. Fuhrer J. Ahnn S. Gelato MC. Insulin-like growth factor system in patients with HIV infection: effect of exogenous growth hormone administration. JAIDS. 22(1):49-55, 1999

  21.            Mynarcik DC, McNurlan MA, Steigbigel RT, Fuhrer J, Gelato MC.  Association of severe insulin resistance with both loss of limb fat and elevated serum tumor necrosis factor receptor levels in HIV Lipodystrophy.  JAIDS 25(4):312-21, 2000

  22.            Gelato MC. The growth hormone/insulin-like growth factor axis in critical illness. J Ped Endocrinol 13 Suppl 2:1023-9, 2000

  23.            Caso G. Garlick PJ. Gelato MC. McNurlan MA. Lymphocyte protein synthesis is increased with the progression of HIV-associated disease to AIDS. [see comments.]. Clinical Science. 101(6):583-9, 2001

  24.            Grinspoon S. Gelato M. Editorial: The rational use of growth hormone in HIV-infected patients. J Clin Endocrinol & Metabol. 86(8):3478-9, 2001

  25.            Gelato MC. Mynarcik D. McNurlan MA. Soluble tumour necrosis factor alpha receptor 2, a serum marker of resistance to the anabolic actions of growth hormone in subjects with HIV disease. Clinical Science. 102(1):85-90, 2002

  26.            Gelato MC. Mynarcik D. Quick J. Steigbigel R. Fuhrer J. Brathwaite C. Brebbia J. Wax M. McNurlan M. Improved insulin sensitivity and body fat distribution in HIV-infected patients treated with rosiglitazone: a pilot study.  JAIDS.  31:163-170, 2002

  27.            Kho SA, Nieman LK, Gelato MC. Cushing’s Diesease aftyer surgery and radiation therapy for a non-functioning pituitary adenoma. Endocrine practice 8:4-8, 2002.

  28.            Mynarcik D. Combs T. McNurlan MA. Scherer PE, Gelato MC. Acrp30 and Leptin Levels in HIV-infected Subject with Insulin Resistance and Body Fat Redistribution. JAIDS. 31:514-520, 2002.

  29.            Gelato, MC.  Insulin and carbohydrate dysregulation.  Clin Infect Dis 36 (Suppl 2): S91-5, 2003.

  30.            Mynarcik D, Wei LX, Komaroff E, Ferris R, McNurlan M, Gelato M. Loss of subcutaneous adipose tissue in HIV-associated lipodystrophy is not due to accelerated apoptosis. J Acquir Immune Defic Syndr. 2005 Jan 1;38(1):53-6. Erratum in: J Acquir Immune Defic Syndr. 2005 Mar 1;38(3):366. Corrected and republished in: J Acquir Immune Defic Syndr. 2005 Mar 1;38(3):367- 71.

  31.            Gelato MC. Growth Hormone-Releasing Hormone: Clinical perspectives revisited. Endocrinologist 15:159-164, 2005.

 

C.      Research Support.  List selected ongoing or completed (during the last three years) research projects (federal and non-federal support). Begin with the projects that are most relevant to the research proposed in this application. Briefly indicate the overall goals of the projects and your role (e.g. PI, Co-Investigator, Consultant) in the research project. Do not list award amounts or percent effort in projects.

 

09/30/05-08/31/10

K30 Award(Gelato)                                                                                        

NIH/NCRR

Clinical Research Education Training Award

The grant is to establish a program/curriculum for clinical research education.

 

6/01/05-6/01/10

RO1 (Gelato) AT002499-01A1                                                                                              

NIH-NCCAM

A Novel Therapy for Glucose Intolerance in HIV Disease

The objective of this study is to test the safety and efficacy of chromium picolinate as a therapy for insulin resistance in HIV + patients.

 

7/01/04-6/30/08

RO1 (Gelato) DK049316-09                                                                          

NIH-NIDDK

PPAR Mediated Gene Expression in HIV Patients

This project seeks to establish that the metabolic syndrome of HIV-associated lipodystrophy including body fat redistribution, insulin resistance, and hyptetriglyceridemia is due to a reduction in the native ligand for the peroxisome proliferators-activated receptor (PPAR) in adipose tissue, skeletal muscle, and liver.

 

12/01/01 - 11/30/06

RR1 071002 (Edelman)                                                                                 

NIH/NCRR                                                                  

General Clinical Research Center

A clinical site for a general clinical research center that provides core support to researchers.

 

 

8/15/01 - 7/31/06

1RO1 AG17446-01A2 (McNurlan)                                                                             

NIH-NIA                                                                                               

Cellular Mechanisms for Sarcopenia in the Elderly

The objective of this project is to investigate the hypothesis that sarcopenia in the elderly results from both a reduction in the basal rate of muscle protein synthesis and a resistance to trophic hormones such as IGF-I caused by chronic inflammation and the mechanism for both reduced basal muscle protein synthesis and increased resistance to anabolic hormones is reduced intracellular insulin/IGF-I signaling.