Positions and Employment

1978-1982       Clinical Associate, NHLBI, Bethesda, MD

1982-1983       Medical Staff Fellow, NHLBI, Bethesda, MD

1983-1990       Senior Investigator, NHLBI, Bethesda, MD

1983-date        Attending Physician, Clinical Center, NIH, Bethesda, MD,;

1990-date        Senior Investigator, NINDS, Bethesda, MD

1992-1999       Chief, Clinical Neurochemistry Section, Clinical Neuroscience Branch, NINDS, Bethesda, MD

1999-date        Chief, Clinical Neurocardiology Section, NINDS, Bethesda, MD

 

Other Experience and Professional Memberships (Partial Listing)

1986-date        Fellow, American College of Physicians

1989-date        Clinical Assoc. Professor of Medicine (Cardiology), Georgetown University School of Medicine, Washington, DC

1996-date        Fellow, American Heart Association

1997-date        Member, Neural Control and Autonomic Regulation Section, American Physiological Society

1999-date        Founding Member, Association for Patient Oriented Research

1999-date        Visiting Professor of Medicine, The Johns Hopkins School of Medicine, Baltimore, MD

2000-date        Member, Board of Directors, National Dysautonomic Research Foundation

2000-date        Member, Autonomic Nervous System Section, American Academy of Neurology

2002-date        Board of Governors, American Autonomic Society

2004-date        IRB, NINDS

2004-date        Visiting Professor of Medicine, Tel Aviv University-Sackler Faculty of Medicine, Israel

2005-date        Executive Board, Association for Patient Oriented Research

 

Honors (Partial Listing)

1970                Angier Prize for Research in Psychology, Yale College

1994                Willem Laufberger Medal, Czech Academy of Sciences, Czech Republic

1994, 2000      NIH Merit Award

2002                Presidential Executive Director’s Award, National Dysautonomic Research Foundation

2004                NIH Distinguished Clinical Teacher Award

2005                John L. Decker Memorial Lecturer, NIH

 

Publications 333 original research articles in peer-reviewed journals, 98 book chapters/reviews, 6 books

 

 

Bibliography (Peer-reviewed original research articles, 2000-date, first-authored only due to space limits):

 

Wong M-L, Kling MA, Munson PJ, Listwak S, Licinio J, Prolo P, Karp B, McCutcheon IA, Goldstein DS, Veldhuis JD, Chrousos GP, Oldfield EH, McCann SM, Gold PW. Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: Relation to hypercotisolism and corticotropin-releasing hormone. PNAS 2000;97:325-330.

Jeong, K-H Jacobson L, Pacak K, Widmaier EP, Goldstein DS, Majzoub JA. Impaired basal and restraint-induced epinephrine secretion in corticotropin-release hormone-deficient mice. Endocrinology 2000;141:1142-1150.

Li S-T, Tack C, Fananapazir L, Goldstein DS. Myocardial perfusion and sympathetic innervation in patients with hypertrophic cardiomyopathy. J Am Coll Cardiol 2000;35:1867-1873.

Goldstein DS, Tack C, Li S-T. Sympathetic innervation and function in reflex sympathetic dystrophy. Ann Neurol 2000;48:49-59.

Frank SM, Raja SN, Bulcao C, Goldstein DS. Age-related thermoregulatory differences during core cooling in humans. Am J Physiol 2000;279:R349-R354.

Goldstein DS, Holmes C, Li S-T, Bruce S, Metman LV, Cannon RO III. Cardiac sympathetic denervation in Parkinson disease. Ann Intern Med 2000;133:338-347.

Pacak K, Linehan WM, Eisenhofer G, Walther MM, Goldstein DS. Recent advances in genetics, diagnosis, localization, and treatment of pheochromocytoma. Ann Intern Med 2001;134:315-329.

Pacak K, Fojo T, Goldstein DS, Eisenhofer G, Walther MM, Linehan WM, Bachenheimer L, Abraham J, Wood BJ. Radiofrequency ablation: A novel approach for treatment of metastatic pheochromocytoma. J Nat Cancer Inst 2001;93:648-649.

Eisenhofer G, Walther MM, Huynh T-T, Li S-T, Bornstein SR, Vortmeyer A, Mannelli M, Goldstein DS, Linehan WM, Lenders JWM, Pacak K. Pheochromocytomas in von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2 display distinct biochemical and clinical phenotypes. J Clin Endocrinol Metab 2001;86:1999-2008.

Pacak K, Goldstein DS, Doppman JL, Shulkin BL, Udelsman R, Eisenhofer G. A “pheo” lurks: Novel approaches for localizing occult pheochromocytoma. J Clin Endocrinol Metab 2001;86: 3641-3646.

Li XX, Bek M, Asico LD, Yang Z, Grandy DK, Goldstein DS, Rubinstein M, Eisner GM, Jose PA. Adrenergic and endothelin b receptor-dependent hypertension in dopamine receptor type-2 knockout mice. Hypertension 2001;38:303-308.

Goldstein DS, Li S-T, Kopin IJ. Sympathetic neurocirculatory failure in Parkinson disease: Evidence for an etiologic role of a-synuclein. Ann Intern Med 2001;135:1010-1011.

Pacak K, Eisenhofer G, Li S-T, Goldstein DS. 6-[¹⁸F]Fluorodopamine positron emission tomographic (PET) scanning for diagnostic localization of pheochromocytoma. Hypertension 2001;38:6-8.

Goldstein DS, Katzper M, Linares O, Kopin IJ. Kinetic model for the fate of the sympathoneural imaging agent 6-[¹⁸F]fluorodopamine in the human heart: A novel means to assess cardiac sympathetic neuronal function. Naunyn-Schmiedeberg’s Arch of Pharmacol 2002;365:38-49.

Frank SM, Goldstein DS. Threshold for adrenomedullary activation and increased cardiac work during mild core hypothermia in awake humans. Clin Sci 2002;102:119-125.

Lenders JWM, Pacak K, Walther MM, Linehan WM, Mannelli M, Friberg P, Keiser HR, Goldstein DS, Eisenhofer G. Biochemical diagnosis of pheochromocytoma: which test is best? JAMA 2002;287:1427-1434.

Goldstein DS, Holmes C, Dendi R, Bruce S, Li S-T. Orthostatic hypotension from sympathetic denervation in Parkinson’s disease. Neurology 2002;58:1247-1255.

Dendi R, Goldstein DS. Meta-analysis of nonselective versus beta-1 adrenoceptor-selective blockade in prevention of tilt-induced neurocardiogenic syncope. Am J Cardiol 2002;89:1319-1321.

Patel JN, Coppack SW, Goldstein DS, Miles JM, Eisenhofer G. Norepinephrine spillover from human adipose tissue before and after a 72-hour fast. J Clin Endocrinol Metab 2002;87:3373-3377.

Elman I, Goldstein DS, Green AI, Eisenhofer G, Folio CJ, Pickar D, Breier A. Effects of resperidone on the peripheral noradrenergic system in patients with schizophrenia: A comparison with clozapine and placebo. Neuropsychopharmacology 2002;27:293-300.

Jordan J, Lipp A, Tank J, Schroder C, Stoffels M, Franke G, Diedrich A, Arnold G, Goldstein DS, Sharma AM, Luft FC. Catechol-O-methyl-transferase and blood pressure in humans. Circulation 2002;106:460-465.

Li S-T, Dendi R, Holmes C, Goldstein DS. Progressive loss of cardiac sympathetic innervation in Parkinson’s disease. Ann Neurol 2002;52:220-223.

Pacak K, Tjurmina O, Palkovits M, Goldstein DS, Koch CA, Hoff T, Chrousos GP. Chronic hypercortisolemia inhibits dopamine synthesis and turnover in the nucleus accumbens: An in vivo microdialysis study. Neuroendocrinology 2002;76:148-157.

Goldstein DS, Holmes C, Dendi R, Li S-T, Brentzel S, Vernino S. Pandysautonomia associated with impaired ganglionic neurotransmission and a neuronal nicotinic receptor antibody. Clin Auton Res 2002;12:281-285.

Goldstein DS, Holmes C, Frank SM, Cannon RO III. Cardiac sympathetic innervation and function in chronic orthostatic intolerance syndromes. Circulation 2002;106:2358-2369.

Goldstein DS, Robertson D, Esler M, Straus SE. Dysautonomias: Clinical disorders of the autonomic nervous system. Ann Intern Med 2002;137:753-763.

Tack C, Goldstein DS. Local sympathetic denervation in patients with painful diabetic neuropathy. Diabetes 2002;51:3545-3553.

Tjurmina OA, Armando I, Saavedra JM, Goldstein DS, Murphy DL. Exaggerated adrenomedullary response to immobilization in mice with targeted disruption of the serotonin transporter gene. Endocrinology 2002;143:4520-4526.

Sharabi Y, Li S-T, Dendi R, Holmes C, Goldstein DS. Neurotransmitter specificity of sympathetic denervation in Parkinson’s disease. Neurology 2003;60:1036-1039.

Goldstein DS, Holmes C, Frank SM, Naqibuddin M, Dendi R, Snader S, Calkins H. Sympathoadrenal imbalance before neurocardiogenic syncope. Am J Cardiol 2003;91:53-58.

Sun M, Zhang G-r, Kong L, Holmes C, Wang X, Goldstein DS, Geller AI. Correction of a rat model of Parkinson’s disease by coexpression of tyrosine hydroxylase and aromatic amino acid decarboxylase from a helper virus-free HSV-1 vector. Hum Gene Ther 2003;14:415-424.

Goldstein DS, Holmes C, Sharabi Y, Brentzel S, Eisenhofer G. Plasma levels of catechols and metanephrines in neurogenic orthostatic hypotension. Neurology 2003;60:1327-1332.

Goldstein DS, Holmes C, Sharabi Y, Eisenhofer G. Cerebrospinal fluid levels of catechols in neurogenic orthostatic hypotension. Clin Sci 2003;104:649-654.

Eisenhofer G, Goldstein DS, Walther MM, Lenders JWM, Friberg P, Keiser HR, Pacak K. Biochemical diagnosis of pheochromocytoma: How to distinguish true- from false-positive test results. J Clin Endocrinol Metab 2003;88:2656-2666.

Sharabi Y, Dendi R, Holmes C, Goldstein DS. Baroreflex failure as a late sequela of neck irradiation. Hypertension 2003;42:110-116.

Goldstein DS, Pechnik S, Holmes C, Eldadah B, Sharabi Y. Association between supine hypertension and orthostatic hypotension in autonomic failure. Hypertension 2003:42:136-142.

Kaufmann H, Saadia D, Voustianiouk A, Goldstein DS, Holmes C, Yahr MD, Nardin R, Freeman R. Norepinephrine precursor therapy in neurogenic orthostatic hypotension. Circulation 2003;108:724-728.

Goldstein DS, Li S-T, Holmes C, Bankiewicz K. Sympathetic innervation in the MPTP primate model of Parkinsons’s disease. J Pharmacol Exp Ther 2003;306:855-860.

Li S-T, Holmes C, Kopin IJ, Goldstein DS. Aging-related changes in cardiac sympathetic function in humans, assessed by 6-[18F]fluorodopamine positron emission tomographic scanning. J Nucl Med 2003;44:1599-1603.

Goldstein DS, Holmes C. Vasodilation during systemic tyramine infusion. Circulation 2004 109:E17-E18.

Singleton A, Gwinn-Hardy K, Sharabi Y, Li S-T, Holmes C, Dendi R, Hardy J, Singleton A, Crawley A, Goldstein DS. Association between cardiac sympathetic denervation and parkinsonism caused by a-synuclein gene triplication. Brain 2004;127:768-772.

Eldadah B, Pacak K, Holmes C. Sharabi Y, Kopin IJ, Eisenhofer G, Goldstein DS. Cardiac uptake-1 inhibition by high circulating norepinephrine concentrations in patients with pheochromocytoma. Hypertension 2004;43:1227-1232.

Sharabi Y, Zimlichman R, Mansouri R, Chun J, Goldstein DS. Does acetylcholinesterase inhibition affect catecholamine secretion by adrenomedullary cells? Isr Med Assoc J. 2004;6:396-369.

Goldstein DS, Pechnik S, Moak J, Eldadah B. Painful sweating. Neurology 2004;63:1471-1475.

Schroeder C, Tank J, Goldstein DS, Stoeter M, Haertter S, Luft FC, Jordan J. Influence of St. John’s wort on catecholamine turnover and cardiovascular regulation in humans. Clin Pharmacol Ther 2004;76:480-489.

Elman I, Rott D, Green AI, Langleben DD, Lukas SE, Goldstein DS, Breier A. Effects of pharmacological doses of 2-deoxyglucose on plasma catecholamines and glucose levels in patients with schizophrenia. Psychopharmacology 2004;176:369-375.

Eisenhofer G, Huynh T-T, Pacak K, Brouwers FM, Walther MM, Linehan WM, Munson PJ, Mannelli M, Goldstein DS, Elkahloun AG. Distinct gene expression profiles in norepinephrine and epinephrine producing hereditary and sporadic pheochromocytoma hypoxia-driven angiogenic pathways in von Hippel-Lindau syndrome.  Endocrine-Related Cancer 2004;11:897-911.

Goldstein DS, Holmes C, Kaufmann H, Freeman R. Clinical pharmacokinetics of the norepinephrine precursor L-threo-DOPS in primary chronic autonomic failure. Clin Auton Res 2004;14:363-368.

Goldstein DS, Eldadah B, Holmes C, Pechnik S, Moak J, Sharabi Y. Neurocirculatory abnormalities in chronic orthostatic intolerance. Circulation 2005;111:839-845.

Eisenhofer G, Lenders JWM, Goldstein DS, Mannelli M, Csako G, Walther MM, Brouwers, Pacak K. Pheochromocytoma catecholamine phenotypes and prediction of tumor size and location using plasma free metanephrines. Clin Chem 2005;51:735-744.

Gold PW, Wong ML, Goldstein DS, Gold HK, Ronsaville DS, Esler M, Alesci S, Masood A, Licinio J, Geracioti TD Jr, Perini G, Debellis MD, Holmes C, Vgontzas AN, Charney DS, Chrousos GP, McCann SM, Kling MA. Cardiac implications of increased arterial entry and reversible 24-h central and peripheral norepinephrine levels in melancholia. PNAS 2005;102:8303-8308.

Moak J, Eldadah B, Holmes C, Pechnik S, Goldstein DS. Partial cardiac sympathetic denervation after bilateral thoracic sympathectomy in humans. Heart Rhythm 2005;2:602-609.

Eisenhofer G, Goldstein DS, Sullivan P, Csako G, Brouwers F, Lai EW, Adams KT, Pacak K. Biochemical and clinical manifestations of dopamine-producing paragangliomas: utility of plasma methoxytyramine. J Clin Endcrinol Metab 2005;90:2068-2075.

Holmes C, Moak J, Eldadah B, Zimmerly E, Sharabi Y, Goldstein DS. Dopamine contamination of infused tyramine. Clin Chem 2005;51:1733-1735.

Goldstein DS. Orthostatic hypotension as an early finding in Parkinson disease. Clin Auton Res (in press).

Gold PW, Wong ML, Goldstein DS, Gold HK, Ronsaville DS, Esler M, Alesci S, Masood A, Licinio J, Geracioti TD Jr, Perini GI, Debellis MD, Vgontzas AN, Charney DS, Chrousos GP, McCann SM, Kling MA. Melancholic depressed patients have sympathetic hyperactivity that is reversed by electroconvulsive therapy. PNAS (in press).

 

Bibliography (Chapters or reviews, 2000-date, partial listing due to space limits):

 

Goldstein DS. Sympathetic nervous system. In Fink G (Ed.) Encyclopedia of Stress. New York: Academic Press, 2000, pp. 558-565.

Goldstein DS, Pacak K. Catecholamines in the brain and responses to environmental challenges. In McEwen BS (Ed.) Handbook of Physiology. Coping with the Environment. New York: Oxford Univ. Press, 2000, pp. 45-60.

Goldstein DS, Eisenhofer G. Sympathetic nervous system physiology and pathophysiology in coping with the environment. In McEwen BS (Ed.) Handbook of Physiology. Coping with the Environment. New York: Oxford Univ. Press, 2000, pp. 21-43.

Eisenhofer G, Pacak K, Goldstein DS. ¹²³I-MIBG scintigraphy of catecholamine systems: Impediments to applications in clinical medicine. Eur J Nucl Med 2000;27:611-612.

Goldstein DS. Physiology of the adrenal medulla and the sympathetic nervous system. In Becker KL (Ed.) Principles and Practice of Endocrinology and Metabolism. New York: Lippincott, 2001, pp. 817-826.

Goldstein DS. New clinical techniques to assess cardiac sympathetic innervation and function in dysautonomias. In Orthostatic Intolerance, Neurally Mediated Syncope, and Related Disorders. CME Monograph. San Antonio, TX: The Dannemiller Memorial Educational Foundation, 2001, pp. 5-7.

Goldstein DS. Cardiac sympathetic neuroimaging to distinguish multiple system atrophy from Parkinson disease. Clin Auton Res 2001;11:341-342.

Goldstein DS. Adrenaline and Noradrenaline. Encyclopedia of Life Sciences. London: Macmillan Reference Limited, 2001, pp. 1-8.

Goldstein DS, Holmes CS, Frank SM. Stressor-specific activation of catecholamine systems in humans. In Nagatsu T, Nabashima T, Goldstein DS (Eds.) Catecholamine Research: From Molecular Insights to Clinical Medicine. New York: Plenum, 2002, pp. 333-336.

Goldstein DS. Cardiac sympathetic denervation in Parkinson’s disease. In Nagatsu T, Nabashima T, Goldstein DS (Eds.) Catecholamine Research: From Molecular Insights to Clinical Medicine. New York: Plenum, 2002, pp. 443-448.

Pacak K, Tjurmina O, Palkovis M, Goldstein DS, Koch CA, Hoff T, Goldsmith P, Chrousos GP. Chronic hypercortisolemia inhibits dopaminergic activity in the nucleus accumbens. In McCarty R, Aguilera G, Sabban E, Kvetnansky R (Eds.) Stress. Neural, Endocrine and Molecular Studies. New York: Taylor & Francis, 2002, pp. 33-36.

Goldstein DS, Elman I, Frank SM, Lenders JWM. Stressor-specific activation of catecholaminergic systems: Clinical demonstrations.  In McCarty R, Aguilera G, Sabban E, Kvetnansky R (Eds.) Stress. Neural, Endocrine and Molecular Studies. New York: Taylor & Francis, 2002, pp. 249-253.

Goldstein DS. Sympathetic System Insufficiency/ Dysautonomia. In Chrousos GP (Ed.) The Adrenal Gland. Endotext.org., Medtext.com, 2002.

Goldstein DS, McEwen B. Commentary: Allostasis, homeostats, and the nature of stress. Stress 2002; 5:55-58.

Pacak K, Eisenhofer G, Carrasquillo JA, Chen CC, Whatley M, Goldstein DS. Diagnostic localization of pheochromocytoma: The coming of age of positron emission tomography. Ann N Y Acad Sci. 2002;970:170-176.

Goldstein DS, Eisenhofer G. Catecholamine synthesis, release, reuptake, and metabolism. In Izzo J, Black HR (Eds.) Hypertension Primer. Dallas, TX: American Heart Association, 2003, pp. 5-7.

Goldstein DS. Catecholamines and stress. Endocrine Regul 2003;37:69-80.

Goldstein DS, Eisenhofer G, Kopin IJ. Sources and significance of plasma levels of catechols and their metabolites in humans. J Pharmacol Exp Ther 2003;305:800-811.

Cuajungco MP, Ando Y, Axelrod FB, Biaggioni I, Goldstein DS, Guttmacher AE, Gwinn-Hardy K, Hahn MK, Hilz MJ, Jacob G, Jens J, Kennedy WR, Liggett SB, O'Connor DT, Peltzer SR, Robertson D, Rubin BY, Scudder Q, Smith LJ, Sonenshein GE, Svejstrup JQ, Xu Y, Slaugenhaupt SA. Hereditary dysautonomias: Current knowledge and collaborations for the future. Clin Auton Res 2003;13:180-195.

Goldstein DS. Dysautonomia in Parkinson’s disease: Neurocardiological abnormalities. The Lancet Neurol 2003;2:669-676.

Eisenhofer G, Goldstein DS, Kopin IJ, Crout JR. Pheochromocytoma: Rediscovery as a catecholalmine-metabolizing tumor. Endocr Pathol 2003;14:193-212.

Goldstein DS. Spinal cord stimulation for reflex sympathetic dystrophy. Ann Neurol 2004;55:5-6.

Goldstein DS, Eisenhofer G, Pacak K. Diagnosis and localization of pheochromocytoma: Hypertension Grand Rounds. Hypertension 2004;43:1-4.

Goldstein DS. Imaging of the autonomic nervous system: Focus on cardiac sympathetic innervation. Sem Neurol 2004;23:423-433.

Eisenhofer G, Goldstein DS. Peripheral dopamine systems. In Robertson D, Low PA, Polinsky RJ (Eds.) Primer on the Autonomic Nervous System. New York: Academic Press, 2004, pp. 176-177.

Goldstein DS. Noradrenergic neurotransmission. In Robertson D, Low PA, Polinsky RJ (Eds.) Primer on the Autonomic Nervous System. New York: Academic Press, 2004 pp. 44-59.

Eisenhofer G, Kopin IJ, Goldstein DS, Leaky catecholamines stores: Undue waste or a stress coping mechanism? In Pacak K, Aguilera G, Sabban E, Kvetnansky R (Eds.) Stress. Neural, Endocrine and Molecular Studies. Ann NY Acad Sci 2004;1018:224-230.

Goldstein DS. Functional neuroimaging of sympathetic innervation of the heart.  In Pacak K, Aguilera G, Sabban E, Kvetnansky R (Eds.) Stress. Neural, Endocrine and Molecular Studies. Ann NY Acad Sci 2004;1018:231-243.

Pacak K, Eisenhofer G, Goldstein DS. Functional imaging of endocrine tumors: Role of positron emission tomography. Endocr Rev 2004;25:568-580.

Eisenhofer G, Kopin IJ, Goldstein DS. Catecholamine metabolism: A contemporary view with implications for physiology and medicine. Pharmacol Rev 2004;56:331-349.

Eisenhofer G, Bornstein SR, Brouwers FM, Cheung N-KV, Dahia PL, de Krijger RR, Giordano TJ, Greene LA, Goldstein DS, Lehnert H, Manger WM, Maris JM, Neumann HPH, Pacak K, Shulkin BL, Smith DI, Tischler AS, Young WF Jr. Malignant pheochromocytoma: current status and initiatives for future progress. Endocrine-Related Cancer 2004;11:423-436.

Goldstein DS. Merging of the homeostat theory with the concept of allostatic load. In Schulkin J (Ed.) Allostasis, Homeostasis, and the Costs of Physiological Adaptation. New York: Cambridge University Press 2004, pp. 99-112.

Goldstein DS. Case 7-2004: Multiple-system atrophy. N Engl J Med 2004;351:2881-2883.

Goldstein DS. Cardiovascular autonomic dysfunction. In Pfeiffer RF, Bodis-Wollner I (Eds.) Parkinson’s Disease and Nonmotor Dysfunction. New York: Humana Press, 2005, pp. 149-157.

Goldstein DS. The autonomic nervous system and disorders of autonomic cardiovascular regulation. Isr Med Assoc J (in press).

Goldstein DS. Sympathoadrenal imbalance before neurocardiogenic syncope. In Proceedings, Third International Congress on Heart Disease. Bologna, Italy: Moduzzi Editore (in press).

Goldstein DS. Cardiac sympathetic neuroimaging. In Proceedings, Cardiovascular Molecular Imaging, Society for Nuclear Medicine (in press).

Goldstein DS. Complex regional pain syndromes. In Johnson RT, Griffin JW, McArthur JC (Eds), Current Therapy in Neurological Diseases. New York: Elsevier. Volume 7 (in press).

Goldstein DS. Sympathetic nervous system. In Fink G (Ed.) Encyclopedia of Stress. New York: Academic Press (in press).

Kaufmann H, Goldstein DS. Dysautonomia in Parkinson disease. Handbook of Clinical Neurology (in press).

 

Bibliography (Books, 2000-date):

 

1.            Goldstein DS. The Autonomic Nervous System in Health and Disease, New York: Marcel Dekker, Inc., 2001.

2.            Nagatsu T, Nabashima T, McCarty R, Goldstein DS (Eds.) Catecholamine Research: From Molecular Insights to Clinical Medicine. New York: Plenum, 2002.