BIOGRAPHICAL SKETCH

Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
Follow this format for each person.  DO NOT EXCEED FOUR PAGES.

 

NAME

Ellen W. Seely

POSITION TITLE

Associate Professor of Medicine

eRA COMMONS USER NAME

 

EDUCATION/TRAINING  (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATION

DEGREE

(if applicable)

YEAR(s)

FIELD OF STUDY

Brown University

B.A.

1977

Biology

Columbia University

M.D.

1981

Medicine

 

 

 

 

A.      Positions and Honors.

      1987‑1991      Instructor in Medicine, Harvard Medical School, Boston, MA.

1991‑2001 Assistant Professor in Medicine, Harvard Medical School, Boston, MA.

2001-       Associate Professor in Medicine, Harvard Medical School, Boston MA

Hospital Appointments

1987‑1994 Associate Physician, Brigham and Women's Hospital, Boston, MA.

1987-                       Research, Endocrine‑Hypertension Division, Brigham and Women's Hospital,

1988-                             Boston, MA.

1994-         Associate Program Director, GCRC.

1996-                 Physician, Brigham and Women's Hospital, Boston, MA

      2001-      Faculty Mentor, Department of Medicine’s Mentoring Program, BWH

Memberships in Professional Societies

      1989      Member, Endocrine Society           

      1992-      Member, International Society for the Study of Hypertension in Pregnancy  

      1992-      Member, American Diabetes Association          

      1995-      Fellow, Council for High Blood Pressure Research

      2001-      Member, North American Society for the Study of Hypertension in Pregnancy

2003-                 Member, Research Affairs Committee, Endocrine Society

      2005-      Secretary/Treasurer Association for Patient-Oriented Research

Honors

      1994-1996      Capps Scholar in Diabetes, Harvard Medical School

      1999                     Hypertension Specialist in Clinical Hypertension, American Society of Hypertension.

      2000               Smith-Kline Beecham Faculty Award in Diabetes, Brigham and Women’s Hospital

      2002                     A. Clifford Barger Excellence in Mentoring Award, Harvard Medical School

      2002               Distinguished Member of the Society of Teaching Scholars, Brigham and Women’s  

                                   Hospital

 

B. Selected peer-reviewed publications (in chronological order).

1.      Seely EW, Moore TJ, Rogacz S, Gordon M, Gleason RE, Hollenberg NK, Williams GH.  Angiotensin‑mediated renin suppression is altered in non‑modulating hypertension.  Hypertension 1989; 13:31‑7.

2.      Seely EW, LeBoff MS, Chen C, Posillico JT, Brown EM, Hollenberg NK, Williams GH.  The calcium‑channel blocker diltiazem lowers parathyroid hormone (PTH) levels in vivo and in vitro.  J Clin Endocrinol Metab 1989; 68:1007‑12.

3.      Seely EW, Conlin PR, Brent GA, Dluhy RG.  Adrenocorticotropin stimulation of aldosterone:  prolonged continuous versus pulsatile infusion.  J Clin Endocrinol Metab 1989; 69:1028‑32.

4.      Mandel SJ, Larsen PR, Seely EW, Brent GA. Increased need for thyroxine during pregnancy in women with primary hypothyroidism.  N Engl J Med 1990; 323:91‑96. 

5.      Seely EW, Williams GH, Graves SW.  Markers of sodium homeostasis in pregnancy‑induced hypertension. 

      J Clin Endocrinol Metab 1992; 74:150‑6. 

6.      Grant FD, Mandel SJ, Brown EM, Williams GH, Seely EW.  Interrelationships between the renin‑angiotensin‑aldosterone and calcium homeostatic systems.  J Clin Endocrinol Metab 1992; 75:988‑992.

7.      Graves SW, Moore TJ, Seely EW.  Increased platelet angiotensin II number in women with pregnancy‑induced hypertension.  Hypertension 1992; 20:627‑632. 

8.      Seely EW, Canessa ML, Graves SW. Impact of diabetes on sodium‑lithium‑countertransport in pregnancy‑induced hypertension.  Am J Hypertens 1993: 6:422‑426. 

9.      Graves SW, Wood RJ, Brown EM, Seely EW.  Calcium and calciotropic hormones in transient hypertension of pregnancy versus preeclampsia.  Hypertens in Pregnancy 1994; 13:87‑95. 

10.  Solomon CG, Graves SW, Greene MF, Seely EW.  Glucose intolerance as a predictor of hypertension in pregnancy.  Hypertens 1994; 23:717‑721. 

11.  Gaboury C, Simonson DL, Seely EW, Hollenberg NK, Williams GH.  Relation of vascular responsiveness and insulin resistance in hypertension.  J Clin Invest 1994; 94:2295-2300. 

12.  Graves SW, Lincoln K, Cook SL, Seely EW.  Digitalis‑like factor and digoxin‑like immunoreactive factor in diabetic women with preeclampsia, transient hypertension of pregnancy, and normotensive pregnancy.  Am J Hypertens 1995; 8:5-11. 

13.  Solomon CG, Graves SW, Greene MF, Seely EW.  Glucose intolerance as a predictor of hypertension in pregnancy.  Hypertens 1994; 23:717‑721. 

14.  Seely EW, Brown EM, DeMaggio DM, Weldon DK, Graves SW.  A prospective study of calciotropic hormones in pregnancy and the postpartum state:  Reciprocal changes in serum intact parathyroid hormone and 1,25-dihydroxyvitamin D. Am J Ob Gyn 1997;176:214-17. 

15.  Fisher ND, Ferri C, Bellini C, Santucci A, Gleason R, Williams GH, Hollenberg NK, Seely EW.  Age, gender and non‑modulation:  A sexual dimorphism in essential hypertension.  Hypertension 1997; 29:980-985. 

16.  Solomon CG, Carroll JS, Okamura K, Graves SW, Seely EW.  Higher cholesterol and insulin levels are associated with increased risk for pregnancy-induced hypertension. Am J Hypertens 1999, 276-828. 

17.  Seely EW, Walsh BW, Gerhard MD, Williams GH. Estradiol with or without progesterone and ambulatory blood pressure in postmenopausal women. Hypertens 1999;33:1190-1194. 

18.  Seely EW.  Hypertension in pregnancy: A potential window into long-term cardiovascular risk in women.  J Clin Endocriol  Metab 1999; 84:1858-1861. 

19.  Wyckoff JA, Seely EW, Hurwitz S, Anderson BF, Lifton RP, Dluhy RG.  Glucocorticoid-remediable aldosteronism and pregnancy.  Hypertension 2000; 35:668-672. 

20.  Marqusee E, Braverman LE, Lawrence JE, Carroll JS, Seely EW.  The effect of droloxifene and estrogen on thyroid function in postmenopausal women.  J Clin Endocrinol Metab 2000; 85:4407-4410. 

21.  Raji A, Williams GH, Xavier J, Hopkins PN, Hunt SC, Hollenberg NK, Seely EW.     Insulin resistance is affected by sodium intake in non-modulating subset of essential hypertension. Am J Hypertens 2001; 19:99-105.  

22.  Seely EW, Carrol JA, Goodfriend TL, Tao Q-F, Graves SW.  Digitalis-like factor response to hyperinsulinemia in human pregnancy, a model of insulin resistance.  J Hum Hypertens 2002; 16(12): 851-6. 

23.  Raji A, Seely EW, Bekins SA, Williams GA, Simonson DC.  Rosiglitazone improves insulin sensitivity and lowers blood pressure   in hypertensive patients.  Diabetes Care 2003; 26(1):172-178. 

24.  Seely EW, Solomon CG.  Insulin resistance and its potential role in pregnancy-induced hypertension.; J Clin Endocrinol Metab 2003; 88:2393-2398.  

25.  Seely EW, Brosnihan KB, Jeunemaitre X, Okamura K, Williams, MD GH, Hollenberg NK, Herrington DM. Effects of conjugated estrogen and droloxifene on the renin-angiotensin system, blood pressure and renal blood flow in postmenopausal women. Clinical Endocrinology, 2004; 60:315-321. 

26.  Bentley-Lewis R, Graves SW, Seely EW. The renin-aldosterone response to stimulation and suppression during normal pregnancy. Hypertension in Pregnancy. 2005; 24:1-16. 

27.  Wyatt JW, Hoyme HE, Jovanovic L, Kaaja R, Brown F, Garg S, Lee- Parritz A, Seely EW, Kerr L, Mattoo V, Tan M, and the IONS  study group. Congenital anomaly rate in offspring of mothers with diabetes treated with insulin lispro during pregnancy.  Diabetes Medicine 2005;22:803-807. 

28.  25. Heitritter S, Solomon CG, Mitchell G, Skali NO, Seely EW.  Subclinical inflammation and vascular dysfunction in women with prior  gestational diabetes.  J Clin Endocrinol Metab. 2005;90:3983-3988.